个人履历

牛湘衡，男，博士，江苏大学绿色化学与化工技术研究院，硕士生导师

教育经历

2010/09-2015/03，华东理工大学，化学与分子工程学院，分析化学，博士

2006/09-2010/06，华东理工大学，化学与分子工程学院，应用化学，学士

工作经历

2017/06-至今，江苏大学绿色化学与化工技术研究院，副研究员

2015/07-2017/05，江苏大学绿色化学与化工技术研究院，助理研究员

研究方向

纳米酶分析化学（新型高效纳米酶的开发及其在环境检测与临床诊断中的应用）

专著/章节

1. Nanostructured Materials for Electrocatalysis and Electroanalysis of Small Biological Molecules, 2017年 (章节)

2. Smartphone-Based Sensors for On-Site Rapid Water Quality Monitoring, 2019年 (章节)

承担项目

主持国家自然科学青年基金、江苏省自然科学基金、国家博士后基金、江苏省博士后基金等

学术论文（第一作者/通讯作者）

[1] Xiangheng Niu*, Yanfang He, et al. A peroxidase-mimicking nanosensor with Hg²⁺-triggered enzymatic activity of cysteine-decorated ferromagnetic particles for ultrasensitive Hg²⁺ detection in environmental and biological fluids. Sensors and Actuators B: Chemical, 2019, 281: 445-452

[2] Xiangheng Niu*, Qiurong Shi, et al. Unprecedented peroxidase-mimicking activity of single-atom nanozyme with atomically dispersed Fe─N_x moieties hosted by MOF derived porous carbon. Biosensors and Bioelectronics, 2019, 142: 111495

[3] Xuechao Xu, Xiangheng Niu*, et al. In situ formation of fluorescent polydopamine catalyzed by peroxidase-mimicking FeCo-LDH for pyrophosphate ion and pyrophosphatase activity detection. Analytica Chimica Acta, 2019, 1053: 89-97

[4] Xiangheng Niu*, Kun Ye, et al. Pyrophosphate-mediated on-off-on oxidase-like activity switching of nanosized MnFe₂O₄ for alkaline phosphatase sensing. Journal of Analysis and Testing, 2019, In press

[5] Xin Li, Xiangheng Niu*, et al. Highly sensitive and specific colorimetric detection of phosphate by using Zr(Ⅳ) to synergistically suppress the peroxidase-mimicking activity of hydrophilic Fe₃O₄ nanocubes. Sensors and Actuators B: Chemical, 2019, 297: 126822

[6] Kun Ye, Xiangheng Niu*, et al. Bifunctional MIL-53(Fe) with pyrophosphate-mediated peroxidase-like activity and oxidation-stimulated fluorescence switching for alkaline phosphatase detection. Journal of Materials Chemistry B, 2019, 7: 4794-4800

[7] Wenchi Zhang, Xiangheng Niu*, et al. Pd nanoparticle-decorated graphitic C₃N₄ nanosheets with bifunctional peroxidase mimicking and on-off fluorescence enable naked-eye and fluorescent dual-readout sensing of glucose. Journal of Materials Chemistry B, 2019, 7: 233-239

[8] Xiangheng Niu*, Kun Ye, et al. A review on emerging principles and strategies for colorimetric and fluorescent detection of alkaline phosphatase activity. Analytica Chimica Acta, 2019, In press

[9] Hongwei Song, Xiangheng Niu*, et al. Colorimetric evaluation of the hydroxyl radical scavenging ability of antioxidants using carbon-confined CoO_x as a highly active peroxidase mimic. Microchimica Acta, 2019, 186: 354

[10] Hongwei Song, Xiangheng Niu*, et al. Enzyme-triggered in situ formation of Ag nanoparticles with oxidase-mimicking activity for amplified detection of alkaline phosphatase activity. Analyst, 2019, 144: 2416-2422

[11] Linjie Wang, Xiangheng Niu*, et al. A novel alkaline phosphatase assay based on the specific chromogenic interaction between Fe³⁺ and ascorbic acid 2-phosphate. Analytical Methods, 2019, 11: 2374-2377

[12] Hongwei Song, Xiangheng Niu*, et al. Facile colorimetric detection of alkaline phosphatase activity based on target-induced valence state regulation of oxidase-mimicking Ce-based nanorods. Journal of Materials Chemistry B, 2019, In press

[13] Xuechao Xu, Xiangheng Niu*, et al. Highly sensitive colorimetric detection of arsenite based on reassembly-induced oxidase-mimicking activity inhibition of dithiothreitol-capped Pd nanozyme. Sensors and Actuators B: Chemical, 2019, 298: 126876

[14] Wenchi Zhang, Xiangheng Niu*, et al. A smartphone-integrated ready-to-use paper-based sensor with mesoporous carbon-dispersed Pd nanoparticles as a highly active peroxidase mimic for H₂O₂ detection. Sensors and Actuators B: Chemical, 2018, 265: 412-420

[15] Yanfang He, Xiangheng Niu*, et al. Uricase-free on-demand colorimetric biosensing of uric acid enabled by integrated CoP nanosheet arrays as a monolithic peroxidase mimic. Analytica Chimica Acta, 2018, 1021: 113-120

[16] Xiangheng Niu*, Yanfang He, et al. Elimination of background color interference by immobilizing Prussian blue on carbon cloth: a monolithic peroxidase mimic for on-demand photometric sensing. Sensors and Actuators B: Chemical, 2018, 256: 151-159

[17] Wenchi Zhang, Xiangheng Niu*, et al. Histidine-mediated tunable peroxidase-like activity of nanosized Pd for photometric sensing of Ag⁺. Sensors and Actuators B: Chemical, 2018, 273: 400-407

[18] Hongwei Song, Xiangheng Niu*, et al. Sensitive and selective colorimetric detection of alkaline phosphatase activity based on phosphate anion-quenched oxidase-mimicking activity of Ce(Ⅳ) ions. Analytica Chimica Acta, 2018, 1044: 154-161

[19] Yanfang He, Xiangheng Niu*, et al. A cobalt-based polyoxometalate nanozyme with high peroxidase-mimicking activity at neutral pH for one-pot colorimetric analysis of glucose. Journal of Materials Chemistry B, 2018, 6: 5750-5755

[20] Xuechao Xu¹, Xiangheng Niu¹, et al. A detachable and recyclable electrochemical sensor for high-performance detection of glucose based on boronate affinity. Sensors and Actuators B: Chemical, 2018, 268: 430-437

[21] Xiangheng Niu*, Xuechao Xu, et al. Surface charge engineering of nanosized CuS via acidic amino acid modification enables high peroxidase-mimicking activity at neutral pH for one-pot detection of glucose. Chemical Communications, 2018, 54: 13443-13446

[22] Yanfang He, Xiangheng Niu*, et al. Microwave-assisted fabrication of bimetallic PdCu nanocorals with enhanced peroxidase-like activity and efficiency for thiocyanate sensing. ACS Applied Nano Materials, 2018, 1: 2397-2405

[23] Xin Li, Xiangheng Niu*, et al. Synergistically enhanced peroxidase-like activity of Pd nanoparticles dispersed on CeO₂ nanotubes and their application in colorimetric sensing of sulfhydryl compounds. Journal of Materials Science, 2018, 53: 13912-13923

[24] Xin Li, Xiangheng Niu*, et al. Three hidden talents in one framework: a terephthalic acid-coordinated cupric metal-organic framework with cascade cysteine oxidase- and peroxidase-mimicking activities and stimulus-responsive fluorescence for cysteine sensing. Journal of Materials Chemistry B, 2018, 6: 6207-6211

授权专利

1. 一种基于负载型PdC类过氧化物酶的制备方法及其应用，2019年

2. 通过多巴胺自聚合制备负载型钯碳催化剂的方法及用途，2019年

获奖成果

获得吉林省科技进步二等奖、中国石油和化学工业联合会科技进步二等奖、镇江市科技进步二等奖等